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62687-22-3

中文名稱(chēng) 野菊花內(nèi)酯
英文名稱(chēng) handelin
CAS 62687-22-3
分子式 C32H40O8
分子量 552.66
MOL 文件 62687-22-3.mol
更新日期 2024/12/19 09:29:34
62687-22-3 結(jié)構(gòu)式 62687-22-3 結(jié)構(gòu)式

基本信息

中文別名
野菊花內(nèi)酯
野菊花內(nèi)酯對(duì)照品
野菊花內(nèi)酯標(biāo)準(zhǔn)品
野菊花內(nèi)酯,分析標(biāo)準(zhǔn)品
英文別名
handelin
Yejuhualactone
HANDELIN
YEJUHUALACTONE
6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-2,2'-dioxo-2',3a,3',3a',4,5,5',6,6a,6',7,9a,9b,9',9a',9b'-hexadecahydro-4'H-spiro[azuleno[4,5-b]furan-3,10'-[6a,9]ethanoazuleno[4,5-b]furan]-5-yl acetate
Spiro[azuleno[4,5-b]furan-3(2H),10'-[4H-6a,9]ethanoazuleno[4,5-b]furan]-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3R,3aR,3'aS,4S,6R,6'R,6aR,6'aR,9'R,9aR,9'aS,9bR,9'bS)-
所屬類(lèi)別
生物化工:提取物

物理化學(xué)性質(zhì)

外觀性狀白色粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來(lái)源于野菊花。
沸點(diǎn)731.0±60.0 °C(Predicted)
密度1.34±0.1 g/cm3 (20 ºC 760 Torr)
酸度系數(shù)(pKa)14.34±0.70(Predicted)
形態(tài)Solid
顏色White to off-white

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
用途2
野菊花內(nèi)酯具有清熱解毒,消腫,降壓的作用。

常見(jiàn)問(wèn)題列表

生物活性
Handelin 是來(lái)自Chrysanthemum boreale 的愈創(chuàng)木酚內(nèi)酯二聚體,它通過(guò)下調(diào) NF-κB 信號(hào)傳導(dǎo)和促炎性細(xì)胞因子的產(chǎn)生而具有強(qiáng)大的抗炎活性。
體外研究

Handelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment suppresses the LPS-induced (1 μg/mL) overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Handelin also suppresseS the induction of pro-inflammatory cytokines TNF-α and IL-1β in LPS-stimulated RAW 264.7 cells. Handelin also suppresses the activation of mitogen-activated protein kinases, including ERK and JNK signaling.
Handelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment significantly reduces the iNOS and COX-2 mRNA levels in LPS- stimulated RAW 264.7 cells. The transcriptional activity of NF-κB stimulated with LPS is also suppressed by Handelin. In addition, the LPS-stimulated upregulation of miRNA-155 expression is suppressed by Handelin.

RT-PCR

Cell Line: RAW 264.7 cells
Concentration: 10 μM, 20 μM, 40 μM
Incubation Time: 5 hours
Result: iNOS and COX-2 mRNA levels were significantly reduced. The transcriptional activity of NF-κB stimulated with LPS was also suppressed and the LPS-stimulated upregulation of miRNA-155 expression was also suppressed.

Western Blot Analysis

Cell Line: RAW 264.7 cells
Concentration: 10 μM, 20 μM, 40 μM
Incubation Time:
Result: Suppressed the LPS-induced overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Suppressed the induction of pro-inflammatory cytokines TNF-α and IL-1β, and also also suppressed the activation of mitogen-activated protein kinases, including ERK and JNK signaling in LPS-stimulated RAW 264.7 cells.
體內(nèi)研究

Handelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model .

Animal Model: Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan
Dosage: 10 mg/kg, 20 mg/kg
Administration: Oral administration; for 30 mintues
Result: Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited.
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