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6133-30-8

中文名稱 2-胍基琥珀酸
英文名稱 GUANIDINOSUCCINIC ACID
CAS 6133-30-8
分子式 C5H9N3O4
分子量 175.14
MOL 文件 6133-30-8.mol
更新日期 2024/12/23 09:09:20
6133-30-8 結(jié)構(gòu)式 6133-30-8 結(jié)構(gòu)式

基本信息

中文別名
胍基琥珀酸
L-胍基丁二酸
2-胍基琥珀酸
(S)-2-胍基琥珀酸
英文別名
guanidinosuccic acid
n-amidino-asparticaci
GUANIDINOSUCCINIC ACID
2-Guanidinosuccinic acid
N-AMIDINO-L-ASPARTIC ACID
(S)-GUANIDINOSUCCINIC ACID
alpha-guanidinosuccinicacid
(S)-2-Guanidinosuccinic acid
N-carbamimidoyl-L-aspartic acid
n-(aminoiminomethyl)-l-asparticaci
所屬類別
生物化工:氨基酸及其衍生物

物理化學(xué)性質(zhì)

沸點(diǎn)344.5±52.0 °C(Predicted)
密度1.74±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMSO: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
酸度系數(shù)(pKa)3.22±0.23(Predicted)
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3
RTECS號CI9098875

常見問題列表

生物活性
Guanidinosuccinic acid 是從血清和尿液中分離出的含氮代謝物,在尿毒癥患者的尿液和血清中升高。
靶點(diǎn)

Human Endogenous Metabolite

體內(nèi)研究

Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD 50 (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD 50 of 579 (445-756) mg/kg. The CD 50 of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.

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