59450-89-4
59450-89-4 結構式
基本信息
中文別名
卡西霉素A23187 半鈣鹽
鈣離子載體 A23187 半鈣鹽
英文別名
A23187 HEMICALCIUM SALTCALCIMYCIN A23187 HEMICALCIUM SALT
Antibiotic A-23187 hemicalcium salt
calcium ionophore A23187 hemicalcium
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT
Calcium Ionophore A23187 hemicalcium salt powder
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA
A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
常見問題列表
生物活性
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) 是一種抗生素和獨特的二價陽離子離子載體 (divalent cation ionophore)，如鈣離子和鎂離子。Calcimycin hemicalcium salt 通過增加細胞內(nèi)鈣濃度誘導 Ca2+ 依賴性細胞死亡。Calcimycin hemicalcium salt 抑制革蘭氏陽性細菌和一些真菌的生長，還抑制 ATP 酶的活性并解耦哺乳動物細胞的氧化磷酸化 (OXPHOS)，誘導細胞凋亡 (apoptosis)。體外研究
Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
體內(nèi)研究
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
| Animal Model: | Mice (ICR, 25-30 g) |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |