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59143-60-1

中文名稱 頭孢菌素C鋅鹽
英文名稱 CEPHALOSPORIN C ZINC SALT
CAS 59143-60-1
分子式 C16H19N3O8SZn
分子量 478.79
MOL 文件 59143-60-1.mol
59143-60-1 結(jié)構(gòu)式 59143-60-1 結(jié)構(gòu)式

基本信息

中文別名
頭孢菌素C鋅鹽
頭孢霉素C鈉鹽
-(D-5-氨基-5-羧基戊酰胺基)頭孢霉烷酸鋅鹽
7-(D-5-氨基-5-羧基戊酰胺基)頭孢霉烷酸鋅鹽
(6R,7R)-3-(乙酰氧基甲基)-7 - ((R)-5-氨基-5- 羧基戊酰胺)-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-2-羧酸鋅(II)
英文別名
Einecs 261-624-9
CEPHALOSPORIN C ZINC SALT
CEPHALOSPORIN C ZINC SALT USP/EP/BP
Zinc (6R,7R)-7-[[(5R)-5-Amino-5-carboxylatopentanoyl]amino]-8-oxo-3-(2-oxopropyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Zinc(II) (6R,7R)-3-(acetoxymethyl)-7-((R)-5-amino-5-carboxylatopentanamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-3-[(Acetyloxy)Methyl]-7-[[(5R)-5-aMino-5-carboxy-1-oxopentyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Zinc Salt
zinc [6R-[6alpha,7beta(R*)]]-3-(acetoxymethyl)-7-[(5-amino-5-carboxylato-1-oxopentyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Zinc (6R-(6alpha,7beta(R*)))-3-(acetoxymethyl)-7-((5-amino-5-carboxylato-1-oxopentyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
[6R-[6α,7β(R*)]]-3-[(Acetyloxy)Methyl]-7-[(5-aMino-5-carboxy-1-oxopentyl)aMino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Zinc Salt
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-((5-amino-5-carboxy-1-oxopentyl)amino)-8-oxo-, zinc salt (1:1), (6R-(6alpha,7beta(R*)))-
所屬類別
原料藥:抗真菌類藥

物理化學(xué)性質(zhì)

熔點(diǎn)240-242°C
儲存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度可溶于酸性水溶液(輕微)
形態(tài)結(jié)晶固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H317
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼42/43
安全說明22-45
WGK Germany3
F8

常見問題列表

生物活性
Cephalosporin C zinc salt 是一種有效的 SAMHD1 抑制劑,IC50 值為 1.1 μM。
靶點(diǎn)

IC50: 1.1 μM (SAMHD1)

體外研究

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC 50 of 1.1 ± 0.1 μM, 200-fold more potent than Na + salt form of Cephalosporin C (ICC 50 CC-Na = 213 ± 30 μM).

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