58020-43-2
中文名稱
4-羥基妥洛特羅
英文名稱
1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
CAS
58020-43-2
分子式
C12H18ClNO2
分子量
243.73
MOL 文件
58020-43-2.mol
更新日期
2024/06/12 17:31:27
58020-43-2 結(jié)構(gòu)式
基本信息
中文別名
4-羥基妥洛特羅 英文別名
HOKU 814-Hydroxytulobuterol
4-HYDROXYTULOBUTEROL
HOKU 81
HOKU81
1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
2-Chloro-α-[(tert-butylamino)methyl]-4-hydroxybenzenemethanol
Benzenemethanol,2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-
Benzenemethanol, 2-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-
2-Chloro-alpha-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxybenzenemethanol
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 50 mg/mL (205.15 mM; Need ultrasonic)
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
HOKU-81 (4-Hydroxytulobuterol) 是 Tulobuterol (HY-B1810) 的代謝產(chǎn)物之一。HOKU-81 是一種有效的選擇性 β2-腎上腺素受體刺激劑。HOKU-81 具有支氣管擴(kuò)張作用。靶點(diǎn)
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Beta-2 adrenergic receptor
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體外研究
HOKU-81 (4-Hydroxytulobuterol) is approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs.