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57420-46-9

中文名稱 8-O-乙酰山梔苷甲酯
英文名稱 8-O-acetyl shanzhiside methyl ester
CAS 57420-46-9
分子式 C19H28O12
分子量 448.42
MOL 文件 57420-46-9.mol
更新日期 2024/12/20 18:42:32
57420-46-9 結(jié)構(gòu)式 57420-46-9 結(jié)構(gòu)式

基本信息

中文別名
8-O-乙酰山梔苷甲酯
8-O-乙酰山梔苷甲酯(標(biāo)準(zhǔn)品)
8-O-乙酰山梔苷甲酯, >98%
8-O-乙酰山梔苷甲酯, 來源于獨(dú)一味
8-O-ACETYL SHANZHISIDE METHYL ESTER 8-O-乙酰山梔苷甲酯
英文別名
ND01
Barlerin
UMbroside
8-O-Acetyl shanzhiside methyl
8-Acetylshanzhiside Methyl ester
O-Acetyl Shanzhiside Methyl Ester, 8-
8-O-Acetyl shanzhiside methyl ester, >98%
8-O-Acetyl shanzhiside methyl ester, 98%, from Lamiophlomis rotata (Benth. ex Hook.f.) Kud
7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester
1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester
所屬類別
天然產(chǎn)物:環(huán)烯醚萜衍生物

物理化學(xué)性質(zhì)

外觀性狀類白色結(jié)晶粉末,易溶于甲醇乙醇,來源于獨(dú)一味。
沸點(diǎn)634.2±55.0 °C(Predicted)
密度1.52
溶解度Soluble in methan
酸度系數(shù)(pKa)12.80±0.70(Predicted)
形態(tài)粉末
顏色白色

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:有活化淤血、 止痛止血。
用途2
8-O-乙酰山梔苷甲酯具有止血鎮(zhèn)痛的作用。

安全數(shù)據(jù)

安全說明24/25
海關(guān)編碼29389090

常見問題列表

生物活性
Barlerin (8-O-Acetyl shanzhiside methyl ester) 是從中國(guó)西藏民間藥用植物中分離出的環(huán)孢菌素葡萄糖苷。Barlerin (8-O-Acetyl shanzhiside methyl ester) 可以抑制 NF-κB 活性。
靶點(diǎn)
TargetValue
NF-κB
()
體外研究

Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. . Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.

體內(nèi)研究

Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice.

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