57265-65-3
中文名稱
鈣調(diào)蛋白抑制劑
英文名稱
CALMIDAZOLIUM CHLORIDE
CAS
57265-65-3
分子式
C31H23Cl7N2O
分子量
687.7
MOL 文件
57265-65-3.mol
更新日期
2023/03/20 15:41:25
57265-65-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T106671-(雙(4-氯苯基)甲基)-3-(2-((2,4-二氯芐基)氧基)-2-(2,4-二氯苯基)乙基)-1H-咪唑-3-鎓氯化物
英文別名
R 24571CALMIDAZOLIUM
COMPOUND 48/80
Calimidazoline
COMPOUND R24571
R 24571 CHLORIDE
CALMIDAZOLIUM CHLORIDE
Calmidazolium chloride,99%
CALMODULIN INHIBITOR R 24571
COMPOUND 48/80 TRIHYDROCHLORIDE
物理化學(xué)性質(zhì)
熔點(diǎn)172-176 °C
熔點(diǎn)172-176 °C
儲(chǔ)存條件2-8°C
儲(chǔ)存條件2-8°C
溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol
形態(tài)solid
顏色white
水溶解性Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.
BRN6470244
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331
安全說(shuō)明22-24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGII
WGK Germany3
WGK Germany3
RTECS號(hào)Gk2402500
海關(guān)編碼29332990
常見問題列表
生物活性
Calmidazolium chloride (R 24571) 是一種鈣調(diào)蛋白拮抗劑，拮抗CaM依賴性磷酸二酯酶和鈣調(diào)蛋白誘導(dǎo)的紅細(xì)胞Ca2+轉(zhuǎn)運(yùn)ATP酶活化， IC50 分別為0.15和0.35 μM。也用于抗癌研究。它結(jié)合CaMK的Kd 值為3 nM。靶點(diǎn)
Kd: 3 nM (Calmodulin)
體外研究
Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs.
Cell Viability Assay
| Cell Line: | Mouse F9 ECCs |
| Concentration: | 3, 5, 7, 10 μM |
| Incubation Time: | 30 minutes-24 hours |
| Result: | The IC 50 s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM [2] . |