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56049-88-8

中文名稱 [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
英文名稱 [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
CAS 56049-88-8
分子式 C18H14Cl2O4
分子量 365.21
MOL 文件 56049-88-8.mol
56049-88-8 結(jié)構(gòu)式 56049-88-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T19430
英文別名
Einecs 259-965-3
[[6,7-Dichloro-2-methyl-2-phenyl-1-oxoindan-5-yl]oxy]acetic acid
[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
Acetic acid, 2-[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]-

物理化學(xué)性質(zhì)

熔點167-168 °C(Solv: acetic acid (64-19-7))
沸點553.6±50.0 °C(Predicted)
密度1.422±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.80±0.10(Predicted)

常見問題列表

生物活性
Indacrinone (MK196) 是一種研究性利尿劑,其在大鼠和狗中具有顯著的鹽水活性,并且在黑猩猩中具有尿酸和鹽水活性。
體內(nèi)研究

As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2).

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