55986-43-1
中文名稱
西他苯
英文名稱
CETABEN
CAS
55986-43-1
分子式
C23H39NO2
分子量
361.56
MOL 文件
55986-43-1.mol
更新日期
2024/07/15 17:10:55
55986-43-1 結(jié)構(gòu)式
基本信息
中文別名
西他苯 英文別名
CETABENPeroxisome Proliferator, Cetaben
Benzoic acid, 4-(hexadecylamino)-
HEXADECYLAMINO-P-AMINO BENZOIC ACID
物理化學(xué)性質(zhì)
沸點(diǎn)503.4±33.0 °C(Predicted)
密度0.979±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
酸度系數(shù)(pKa)4.76±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
西他苯價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 5mg | 500元 |
| 2024/11/08 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 10mg | 800元 |
常見問題列表
生物活性
Cetaben 是一種不依賴 PPARα 的過氧化物酶體增殖物。Cetaben 是一種非纖維化降血脂藥，可有效降低膽固醇和甘油三酸酯的濃度。體外研究
Cetaben (10 μM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 μM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
Cetaben-treated (10 μM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.
體內(nèi)研究
Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg.
| Animal Model: | Male Wistar rats |
| Dosage: | 10,25,50,100,250 and 500 mg/kg |
| Administration: | Gavage; 10 day |
| Result: | Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg. |