天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>546-97-4

546-97-4

中文名稱 古倫賓
英文名稱 Columbin
CAS 546-97-4
分子式 C20H22O6
分子量 358.388
MOL 文件 546-97-4.mol
更新日期 2024/12/18 02:38:24
546-97-4 結構式 546-97-4 結構式

基本信息

中文別名
咖倫賓
古倫賓
古倫賓對照品
非洲防己苦素
古倫賓, 來源于青牛膽
COLUMBIN 古倫賓
青牛膽苦素、黃藤內(nèi)酯、防己內(nèi)酯、非洲防己苦素
英文別名
Tinosporin
Columbin USP/EP/BP
Columbin >=95% (LC/MS-ELSD)
Columbin, 98%, from limacia sagittata
(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
(1s,2s,3s,5s,8r,11r,12s)-5-(3-furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione
(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione
1,4-Etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione, 9-(3-furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-, (1R,4R,4aR,6aR,9S,10aS,10bS)-
所屬類別
生物化工:植物提取物

物理化學性質(zhì)

外觀性狀白色針狀結晶,易溶于甲醇、乙酸乙酯,幾乎不溶于水,來源于金國欖。
熔點190-191℃
比旋光度D +52.5° (pyridine)
沸點410.82°C (rough estimate)
密度1.36
折射率1.4450 (estimate)
儲存條件?20°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.03 mg/ml
酸度系數(shù)(pKa)12.14±0.70(Predicted)
形態(tài)Cryst.
顏色White to off-white

應用領域

用途1
古倫賓具有抗菌的作用。

安全數(shù)據(jù)

WGK Germany3
海關編碼29322090

常見問題列表

用途
古倫賓是呋喃內(nèi)酯二萜,是從亞特里薩(Jateorhiza)和丁諾斯菌屬(Tinospora)的根中分離出來的,被用于亞洲和非洲民間醫(yī)學中,具有止痛和解熱的作用。
生物活性
Columbin 是一種口服活性二萜呋喃內(nèi)酯,具有抗炎和抗錐蟲體作用。Columbin 選擇性抑制 COX-2 (EC50=53.1 μM),選擇性高于抑制 COX-1 (EC50=327 μM)。
靶點

COX-2

53.1 μM (EC 50 )

COX-1

327 μM (EC 50 )

體外研究

Treatment with columbin or l-NAME inhibits LPS/IFN-γ-induced NO production without affecting the viability of RAW264.7. Pre-treatment of stimulated cells with columbin does not inhibit the translocation of NF-κB to the nucleus in LPS-stimulated cells. COX-1 and COX-2 inhibitory activities of columbin are 63.7±6.4% and 18.8±1.5% inhibition at 100μM, respectively. The interaction of columbin with Tyr385 and Arg120 signifies its higher activity in COX-2, as Tyr385 is reported to be involved in the abstraction of hydrogen from C-13 of arachidonate, and Arg120 is critical for high affinity arachidonate binding.

體內(nèi)研究

Columbin inhibits oedema formation in mice paw. At doses of 300 mg/kg and 700 mg/kg, columbin inhibits inflammation from 0 to 5 h and the results are comparable to that of aspirin as a standard anti-inflammatory drug. The inhibitory effect of columbin on carrageenan induced paw oedema in mice may be due to the suppression of the release of mediators responsible for inflammation including prostaglandin. Columbin is poorly bioavailable (2.8% p.o. and 14% i.p.) in rats, but its transport is rapid across the Caco-2 cell monolayers, suggesting that extensive first-pass metabolism in the liver is the likely reason for its poor bioavailability.

古倫賓價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08S9167古倫賓
Columbin
546-97-41mg1204.64元
"546-97-4" 相關產(chǎn)品信息
92214-54-5 32981-86-5 28282-25-9 59219-65-7 33286-30-5 196399-16-3 77228-71-8 62067-45-2