54-84-2
54-84-2 結(jié)構(gòu)式
基本信息
maptc
sq10,643
Nsc125717
CINANSERIN
Cinnanserin
DPTC HYDROCHLORIDE
CINANSERIN HYDROCHLORIDE
2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE
DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride
物理化學(xué)性質(zhì)
常見問題列表
|
5-HT 2 Receptor 41 nM (Ki) |
3C-like proteinase
|
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL
pro
, HCoV-229E 3CL
pro
, with the K
D
values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL
pro
and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL
pro
.
The IC
50
values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL
pro
are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC
50
values for HCoV-229E 3CL
pro
are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C
pro
at concentrations up to 200 μM.
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
| Animal Model: | Male Wistar rats (250 g) underwent thermal injury |
| Dosage: | 5 mg/kg |
| Administration: | Intravenous injection; for 2 hours |
| Result: | Significantly reduced systemic burn edema to shamburn levels.. |