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53917-42-3

中文名稱 ACTH (18-39) (HUMAN)
英文名稱 CLIP
CAS 53917-42-3
分子式 C112H165N27O36
分子量 2465.67
MOL 文件 53917-42-3.mol
更新日期 2024/12/22 20:23:42
53917-42-3 結(jié)構(gòu)式 53917-42-3 結(jié)構(gòu)式

基本信息

中文別名
RF-22
人促腎上腺皮質(zhì)激素18-39
人ACTH (18-39)肽
英文別名
CLIP
ACTH 1-39
CLIP (HUMAN)
CORTICOTROPIN A
ACTH (18-39) (HUMAN)
PubChem ID: 16130980
RPVKVYPNGAEDESAEAFPLEF
Adrenocorticotropic hormone fragment
CORTICOTROPIN-LIKE INTERMEDIATE PEPTIDE
corticotropin-likeintermediatelobepeptide

物理化學(xué)性質(zhì)

密度1.49±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度DMF: 2.5mg/mL; DMSO: 5mg/mL; PBS (pH 7.2): 5mg/mL
形態(tài)Solid
序列H-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH

安全數(shù)據(jù)

WGK Germany3

常見(jiàn)問(wèn)題列表

生物活性
Adrenocorticotropic Hormone (ACTH) (18-39), human 是一種似皮質(zhì)促素中葉肽,產(chǎn)生于垂體中葉的促黑素細(xì)胞。
體外研究

The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia.

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