53552-05-9
中文名稱
(-)-荷包牡丹堿甲氯化物
英文名稱
(-)-BICUCULLINE METHOCHLORIDE
CAS
53552-05-9
分子式
C21H20ClNO6
分子量
417.84
MOL 文件
53552-05-9.mol
53552-05-9 結(jié)構(gòu)式
基本信息
中文別名
(-)-荷包牡丹堿甲氯化物(-)-BICUCULLINE METHOCHLORIDE
英文別名
l-Bicuculline methochloride(?)-Bicuculline methochloride
(-)-BICUCULLINE METHOCHLORIDE
[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM CHLORIDE
1,3-Dioxolo[4,5-g]isoquinolinium,5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-,chloride (1:1), (5R)-
所屬類別
醫(yī)藥中間體：吡啶類化合物物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at RT
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)粉末
水溶解性溶于水至100mM
常見(jiàn)問(wèn)題列表
生物活性
(-)-Bicuculline methochloride (l-Bicuculline methochloride) 是一種有效的 GABAA 受體拮抗劑。(-)-Bicuculline methochloride 在神經(jīng)元中阻斷 Ca2+ 激活的 K+ 通道介導(dǎo)的后超極化 (AHPs)。靶點(diǎn)
GABA A
體內(nèi)研究
(-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin.
| Animal Model: | Rat L5-SNL model |
| Dosage: | 0.6 nmol/rat |
| Administration: | Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) |
| Result: | Attenuated the antiallodynic effect of Neurotropin. |