53109-32-3
53109-32-3 結(jié)構(gòu)式
基本信息
(3S,8AS)-六氫-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮
HIS-PRO, CYCLIC
Cyclo-Pro-His-HO
CYCLO(HIS-PRO), >99%
Cyclo(histidyl-proline)
Protirelin EP Impurity E
Cyclo(L-histidyl-L-proline)
histidylproline dioxopiperazine
Histidylproline diketopiperazine
CYCLO(HISTIDYL-PROLINE)
HISTIDYLPROLINE DIKETOPIPERAZINE
物理化學(xué)性質(zhì)
常見問題列表
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NF-κB
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Human Endogenous Metabolite
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cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
| Cell Line: | PC12 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 2, 4, 8, 24, 48 hours |
| Result: | Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
| Animal Model: | Sixty two/three month-old male C57BL/6 mice (25-30 g) |
| Dosage: | 1.8 mg/ear |
| Administration: | Topical application on the right ear; 30 min prior to TPA |
| Result: | Reduced TPA-induced ear oedema. |