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52328-98-0

中文名稱 二甲基姜黃素
英文名稱 ASC-J9
CAS 52328-98-0
分子式 C23H24O6
分子量 396.43
MOL 文件 52328-98-0.mol
更新日期 2024/12/20 18:41:59
52328-98-0 結(jié)構(gòu)式 52328-98-0 結(jié)構(gòu)式

基本信息

中文別名
四甲基姜黃素
二甲基姜黃素
ASC-J9 生產(chǎn)廠家
二甲基姜黃素, ≥95%
英文別名
GO-Y 025
Dimethylcurcumin
Dimethylcurcumin, ≥95%
(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one
1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-
(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one (ASC-J9)
Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】
所屬類別
生物化工:植物提取物

物理化學性質(zhì)

外觀性狀可溶于甲醇、乙醇、DMSO等有機溶劑。
熔點129-130℃
沸點588.6±50.0 °C(Predicted)
密度1.191
儲存條件-20°C儲存
溶解度insoluble in EtOH; insoluble in H2O; ≥16.65 mg/mL in DMSO
酸度系數(shù)(pKa)8.34±0.60(Predicted)
形態(tài)固體
顏色Light yellow to red
二甲基姜黃素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-15194二甲基姜黃素
Dimethylcurcumin
52328-98-05mg540元
2024/11/08HY-15194二甲基姜黃素
Dimethylcurcumin
52328-98-010mM * 1mLin DMSO594元
2024/11/08HY-15194二甲基姜黃素
Dimethylcurcumin
52328-98-010mg900元

常見問題列表

生物活性
Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025)是一種 androgen receptor (AR) 降解促進劑,可通過降解全長和剪接變異體的雄激素受體來抑制去勢抵抗性前列腺癌的生長。
靶點
TargetValue
AR
()
體外研究

Dimethylcurcumin (ASC-J9) is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin (ASC-J9) can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells. Dimethylcurcumin (ASC-J9) (5 or 10 μM) significantly suppresses the DHT-induced cell growth in all three PCa cell lines. Dimethylcurcumin (ASC-J9) suppresses AR-targeted genes and cell growth by degradation of fAR and ectopic AR3 in C81 and C4-2 cells. Dimethylcurcumin (ASC-J9) selectively promotes AR degradation by disrupting the interaction between AR and AR coregulators. ASC-J9 reduces the AR aggregated AR-112Q in cells. Dimethylcurcumin (ASC-J9) suppresses the aggregation of AR-112Q in SBMA PC12/AR-112Q cells.

體內(nèi)研究

Dimethylcurcumin (ASC-J9) (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo, and SC-J9-treated tumors has significantly decreased Ki67-positive cells. Dimethylcurcumin (ASC-J9) (50 mg/kg every 48 h, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice, and ameliorates neuromuscular pathological findings. The Dimethylcurcumin (ASC-J9)-treated SBMA mice have relatively normal serum testosterone concentrations. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen.

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