522649-59-8
中文名稱
ME1
英文名稱
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
CAS
522649-59-8
分子式
C20H21N3O3
分子量
351.4
MOL 文件
522649-59-8.mol
更新日期
2023/03/20 15:41:29
522649-59-8 結(jié)構(gòu)式
基本信息
中文別名
蘋果酸酶抑制劑ME1化合物 T11940
英文別名
Malic Enzyme inhibitor ME12,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
物理化學(xué)性質(zhì)
沸點(diǎn)638.1±55.0 °C(Predicted)
密度1.342±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 125 mg/mL (355.72 mM)
酸度系數(shù)(pKa)12.18±0.30(Predicted)
形態(tài)Solid
顏色White to off-white
ME1價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-124861 | ME1 Malic enzyme inhibitor ME1 | 522649-59-8 | 1mg | 850元 |
| 2024/11/08 | HY-124861 | ME1 Malic enzyme inhibitor ME1 | 522649-59-8 | 10mM * 1mLin DMSO | 1971元 |
| 2024/11/08 | HY-124861 | ME1 Malic enzyme inhibitor ME1 | 522649-59-8 | 5mg | 2550元 |
常見問題列表
生物活性
Malic enzyme inhibitor ME1 (ME1; compound 1) 是一種有效的蘋果酸酶 (ME1) 抑制劑，IC50 為 0.15 μM。靶點(diǎn)
IC50: 0.15 μM (Malic enzyme)
體外研究
Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72?hours) shows a significant reduction in total cell numbers.
Malic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell.
Malic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.
Cell Viability Assay
| Cell Line: | HCT116 and HT29 cell line |
| Concentration: | 50 μM |
| Incubation Time: | 72?hours |
| Result: | Showed a significant reduction in total cell numbers. |