511514-03-7
中文名稱
4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
英文名稱
4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
CAS
511514-03-7
分子式
C21H21N5
分子量
343.42
MOL 文件
511514-03-7.mol
511514-03-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13983 英文別名
1855820990CL
4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-
(4-phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine
物理化學(xué)性質(zhì)
沸點(diǎn)519.5±58.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)
酸度系數(shù)(pKa)7.10±0.60(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
0990CL 是能夠與 Gαi 直接相互作用的，異源三聚體 Gαi subunit 特異性抑制劑。0990CL 能夠阻斷 α2AR 介導(dǎo)的 cAMP 調(diào)節(jié)。靶點(diǎn)
IC50: Gαi subunit
體外研究
0990CL?(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi?mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL?(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi?and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.