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504-96-1

中文名稱 新植二烯
英文名稱 7,11,15-trimethyl-3-methylidene-hexadec-1-ene
CAS 504-96-1
分子式 C20H38
分子量 278.52
MOL 文件 504-96-1.mol
更新日期 2025/01/06 18:58:59
504-96-1 結(jié)構(gòu)式 504-96-1 結(jié)構(gòu)式

基本信息

中文別名
新植二烯
英文別名
Hsdb 4321
Neophytadiene
7,11,15-Trimethyl-3-methylene-1-hexadecene
3-Methylene-7,11,15-trimethylhexadec-1-ene
2-(4,8,12-Trimethyltridecyl)buta-1,3-diene
2-(4,8,12-Trimethyltridecyl)-1,3-butadiene
1-Hexadecene, 7,11,15-trimethyl-3-methylene-
1,3-Butadiene, 2-(4,8,12-trimethyltridecyl)-
7,11,15-trimethyl-3-methylidene-hexadec-1-ene
所屬類別
化學(xué)試劑:烯烴(環(huán)狀與無環(huán)狀)

物理化學(xué)性質(zhì)

沸點144-146 °C(Press: 3.5 Torr)
密度0.8168 g/cm3
儲存條件-20°C冷凍
溶解度Benzene (Slightly), Chloroform (Soluble), Ethyl Acetate (Slightly)
形態(tài)Oil
顏色無色
穩(wěn)定性對光敏感、對溫度敏感
LogP9.522 (est)

安全數(shù)據(jù)

毒害物質(zhì)數(shù)據(jù)504-96-1(Hazardous Substances Data)

常見問題列表

生物活性
Neophytadiene 是一種二萜,能從 Turbinaria ornate 中提取到,具有抗炎、抗氧化和心臟保護作用。
體外研究

Neophytadiene has cytotoxic on RAW 264.7 cells with an IC 50 of 50 μM.
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells.

體內(nèi)研究

Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue.
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo.

Animal Model: Adult male Sprague Dawley rats (6-8 weeks)
Dosage: 12 mg/kg, 25 mg/kg, 50 mg/kg
Administration: Oral administration, daily, for 7 days
Result: Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats.
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