天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>489416-12-8

489416-12-8

中文名稱 489416-12-8
英文名稱 ST-193
CAS 489416-12-8
分子式 C24H25N3O
分子量 371.47
MOL 文件 489416-12-8.mol
489416-12-8 結(jié)構(gòu)式 489416-12-8 結(jié)構(gòu)式

基本信息

中文別名
化合物ST-193
英文別名
ST-193
ST-193 hydrochlorid
ST193 HYDROCHLORIDE
ST 193 HYDROCHLORIDE
1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]-

物理化學(xué)性質(zhì)

沸點(diǎn)562.5±60.0 °C(Predicted)
密度1.12±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: ≥ 150 mg/mL (403.80 mM)
酸度系數(shù)(pKa)5.20±0.10(Predicted)
形態(tài)Solid
顏色Off-white to pink

常見問題列表

生物活性
ST-193是有效廣譜的arenavirus抑制劑;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分別為0.44, 0.62, 1.4 和3.1 nM。
靶點(diǎn)

IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)

體外研究

ST-193 inhibits LASV pseudotypes with an IC 50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC 50 s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM.

體內(nèi)研究

ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.

"489416-12-8" 相關(guān)產(chǎn)品信息