478908-51-9
478908-51-9 結(jié)構(gòu)式
基本信息
英文別名
GGTI-2166L-Leucine, N-[[5-[(1H-imidazol-5-ylmethyl)amino]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
應(yīng)用領(lǐng)域
用途一
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.