466-07-9
中文名稱
黃夾次甙乙
英文名稱
NERIIFOLIN
CAS
466-07-9
分子式
C30H46O8
分子量
534.68
MOL 文件
466-07-9.mol
更新日期
2024/02/02 15:50:27
466-07-9 結(jié)構(gòu)式
基本信息
中文別名
黃夾次甙乙 英文別名
NERIIFOLIN17α-Neriifolin
17β-Neriifolin
xy)-14-hydroxy-
NERIIFOLIN USP/EP/BP
digitoxigenin+thevetose
14-Hydroxy-5β-card-20(22)-enolide 3-(6-deoxy-3-O-methyl-α-L-glucopyranoside)
3β-[(6-Deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide
3β-[(3-O-Methyl-6-deoxy-α-L-glucopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide
3β-(3-O-Methyl-6-deoxy-α-L-glucopyranosyloxy)-14β-hydroxy-5β-carda-20(22)-enolide
所屬類別
生物化工:中草藥成分物理化學(xué)性質(zhì)
熔點218-225°C
比旋光度D23 -50.2° (CH3OH)
儲存條件2-8°C
溶解度可溶于氯仿(少許)、DMSO(少許)、甲醇(少許)、水(少許)
形態(tài)固體
顏色淡黃色
安全數(shù)據(jù)
警示詞危險
危險性描述H300-H330-H310
危險品標(biāo)志T+
危險類別碼26/27/28
安全說明22-36/37/39-45
危險品運輸編號UN 2811 6.1/PG 1
WGK Germany3
RTECS號FH4906100
常見問題列表
生物活性
Neriifolin 是一種穿透中樞神經(jīng)系統(tǒng)的強(qiáng)心苷,是一種Na+, K+-ATPase 的抑制劑。Neriifolin 可靶向 beclin 1,抑制 LC3 相關(guān)吞噬體的形成,改善實驗性自身免疫性腦脊髓炎 (EAE) 的發(fā)展。Neriifolin 誘導(dǎo)人肝癌 HepG2 細(xì)胞周期阻滯和凋亡。體外研究
Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins.