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4542-23-8

中文名稱 (2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
英文名稱 (2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
CAS 4542-23-8
分子式 C14H17N5O8
分子量 383.31
MOL 文件 4542-23-8.mol
4542-23-8 結(jié)構(gòu)式 4542-23-8 結(jié)構(gòu)式

基本信息

中文別名
N6琥珀酰腺苷
英文別名
Succinoadenosine
Succinyladenosine
N6-Succinyl Adenosine
(S)-N-(1,2-Dicarboxyethyl)adenosine
N-<9-(β-ribofuranosyl)-9H-purin-6-yl>-L-aspartic acid
N-(9-β-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartic Acid
6-(1,2-DicarboxyethylaMino) -9-β-D-ribofuranosylpurine
L-Aspartic acid, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-
(2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
(S)-2-((9-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)succinic acid

物理化學(xué)性質(zhì)

熔點(diǎn)>180°C (dec.)
沸點(diǎn)816.4±75.0 °C(Predicted)
密度2.02±0.1 g/cm3(Predicted)
儲存條件-20°C Freezer
溶解度DMSO (Slightly), Methanol (Slightly, Heated)
酸度系數(shù)(pKa)3.52±0.23(Predicted)
形態(tài)Solid
顏色White to Off-White

應(yīng)用領(lǐng)域

用途1
Succinyladenosine (S-Ado) is a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis. 聽S-Ado has been previously reported as normally undetectable in cereb rospinal fluid (CSF) of children not suffering from this defect.

常見問題列表

生物活性
Succinyladenosine,是胞內(nèi)腺苷酸 (S-AMP) 經(jīng) 5-核苷酸酶脫磷酸化的產(chǎn)物,是腺苷酸琥珀酸酶 (ASL) 缺乏的生化標(biāo)志。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

The presence of high concentrations of Succinyladenosine (S-Ado) in the human cerebrospinal fluid (CSF) in the range of 100–500 μmol/L is a diagnostic marker for inherited enzyme deficiency of ASL.

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