4533-39-5
4533-39-5 結(jié)構(gòu)式
基本信息
中文別名
二胺硝吖啶 英文別名
Nitracrine3-(dimethylamino)propyl-(1-nitroacridin-9-yl)amine
N',N'-dimethyl-N-(1-nitroacridin-9-yl)propane-1,3-diamine
1,3-Propanediamine, N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-
物理化學(xué)性質(zhì)
熔點(diǎn)134-135°
沸點(diǎn)462.71°C (rough estimate)
密度1.2155 (rough estimate)
折射率1.6700 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)pKa1 6.45; pKa2 8.8(at 25℃)
形態(tài)Solid
顏色Brown to reddish brown
常見(jiàn)問(wèn)題列表
生物活性
Nitracrine 抑制 RNA 合成 (RNA synthesis)，共價(jià)，可逆地與 DNA 結(jié)合，在體內(nèi)與 DNA 形成共價(jià)加合物。Nitracrine 是 1-nitroacridine 衍生物，一種有效的體外缺氧選擇性藥物和抗腫瘤藥物。Nitracrine 具有細(xì)胞毒性。體外研究
Nitracrine (2 μM; 1 hour) causes death of 50% of human erythroleukemia K562 cells under illumination for 48 min. While it is 8.5 hours for Nitracrine on the dark.
Nitracrine has LD50s of 0.23 μM, 0.6 μM, 0.16 μM in P388 cell, NIH3T3 cell, and K562 cells under illumination after 1 hour of cells incubation, respectively.
Cell Cytotoxicity Assay
| Cell Line: | Human erythroleukemia K562 cells |
| Concentration: | 2 μM |
| Incubation Time: | 1 hour |
| Result: | Death of 50% of human erythroleukemia K562 cells were achieved under illumination for 48 min. |