448906-42-1
448906-42-1 結(jié)構(gòu)式
基本信息
2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯
ARYL HYDROCARBON RECEPTOR LIGAND
Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID
methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER
2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester
4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Ki: 3 nM (AhR)
ITE is an endogenous agonist of AhR, binding directly to AHR, with a K i of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 μM, but shows no effect at 0.01-5 μM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 μM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 μM. In addition, ITE (20 μM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.