4452-06-6
中文名稱
2-萘乙烯基酮
英文名稱
ZM 449829
CAS
4452-06-6
分子式
C13H10O
分子量
182.22
MOL 文件
4452-06-6.mol
更新日期
2024/11/19 11:42:47
4452-06-6 結構式
基本信息
中文別名
2'-萘丙烯酮2-萘乙烯基酮
英文別名
ZM 449829JAK3 INHIBITOR V
2'-Acrylonaphthone
naphthyl vinyl ketone
2-NAPHTHYLVINYL KETONE
1-Naphthalen-2-yl-propenone
1-(2-Naphthyl)-2-propen-1-one
1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE
1-(Naphthalen-2-yl)prop-2-en-1-one
2-Propen-1-one, 1-(2-naphthalenyl)-
所屬類別
生物化工：激動劑抑制劑物理化學性質
沸點319.3±15.0 °C(Predicted)
密度1.093±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形態(tài)白色蠟狀固體
常見問題列表
生物活性
ZM 449829 是有效的、選擇性和 ATP 競爭性的 JAK3 抑制劑，pIC50 值為 6.8。ZM 449829 是可用于研究 JAK3 的藥理學工具。靶點
|
JAK3 6.8 (pIC 50 ) |
JAK1 4.7 (pIC 50 ) |
EGFR 5.0 (pIC 50 ) |
體外研究
ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC
50
=5.0) , Jak1 (pIC
50
=4.7), and tyrosine kinases Lck and CDK4 (pIC
50
<5.0).
ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation.
Western Blot Analysis
| Cell Line: | YTS, NK92, and ex vivo NK cells |
| Concentration: | 1 μM |
| Incubation Time: | 30 minutes pretreatment |
| Result: | Inhibits the phosphorylation of STAT5. |