4366-18-1
4366-18-1 結(jié)構(gòu)式
基本信息
中文別名
庫(kù)美香豆素庫(kù)美香豆素,雙香豆素醚
英文別名
Ph 137Cumetarol
Cumetharol
coumetarol
Dicumoxane
Dicoumoxyl
Cumethoxethan
3,3'-(2-Methoxyethylidene)bis(4-hydroxycoumarin)
2H-1-Benzopyran-2-one, 3,3'-(2-methoxyethylidene)bis[4-hydroxy-
2-hydroxy-3-[1-(2-hydroxy-4-keto-chromen-3-yl)-2-methoxy-ethyl]chromone
物理化學(xué)性質(zhì)
熔點(diǎn)156-157°
沸點(diǎn)639.9±55.0 °C(Predicted)
密度1.514±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.20±1.00(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Coumetarol (Dicumoxane) 是維生素 K 拮抗劑。靶點(diǎn)
vitamin K
體外研究
Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent.