432499-63-3
中文名稱
432499-63-3
英文名稱
4E2RCat
CAS
432499-63-3
分子式
C22H14ClNO4S2
分子量
455.93
MOL 文件
432499-63-3.mol
更新日期
2024/12/15 19:35:20
432499-63-3 結構式
基本信息
中文別名
化合物4E2RCAT化合物 T14044
5-(5-((3-芐基-4-氧代-2-硫噻唑烷-5-亞基)甲基)呋喃-2-基)-2-氯苯甲酸
英文別名
4E2RCatEukaryotic Initiation Factor
Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
物理化學性質
沸點659.0±65.0 °C(Predicted)
密度1.56±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 15.5 mg/mL (34.00 mM)
酸度系數(pKa)2.72±0.25(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
432499-63-3價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100733 | 432499-63-3 4E2RCat | 432499-63-3 | 1mg | 1100元 |
| 2024/11/08 | HY-100733 | 432499-63-3 4E2RCat | 432499-63-3 | 5mg | 2700元 |
| 2024/11/08 | HY-100733 | 432499-63-3 4E2RCat | 432499-63-3 | 10mM * 1mLin DMSO | 2710元 |
常見問題列表
生物活性
4E2RCat是eIF4E-eIF4G相互作用的抑制劑，IC50值為13.5 μM。靶點
IC50: 13.5 μM (eIF4E-eIF4G)
體外研究
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
體內研究
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.