426834-69-7
中文名稱
NS 5806
英文名稱
NS 5806
CAS
426834-69-7
分子式
C16H8Br2F6N6O
分子量
574.07
MOL 文件
426834-69-7.mol
更新日期
2024/11/19 11:42:45
426834-69-7 結(jié)構(gòu)式
基本信息
中文別名
N-[3,5-雙(三氟甲基)苯基]-N'-[2,4-二溴-6-(2H-四唑-5-基)苯基]脲 英文別名
NS 5806N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA
N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea
Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-
常見(jiàn)問(wèn)題列表
生物活性
NS5806 是一種有效的鉀電流激活劑，可增加 KV4.3/KChIP2 峰值電流幅度，EC50 為 5.3 μM。NS5806 會(huì)在包含 KChIP2 的通道復(fù)合體中降低 KV4.3 和 KV4.2 電流衰減。靶點(diǎn)
IC50: 5.3 nM (K V 4.3)
體外研究
NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC
50
value of 25.4 μM in CHO-K1 cells.
NS5806 activates canine transient outward potassium current (Ito) with an IC
50
of 40.7 nM and an EC
50
of 1.6 nM for inhibition and stimulation on rabbit, respectively.
NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito.