412938-67-1
412938-67-1 結構式
基本信息
L-絲氨酰-L-苯丙氨酰-L-精氨酰-L-天冬氨酰胺酰甘氨酰-L-纈氨酰甘氨酰-L-蘇氨酰甘氨酰-L-蛋氨酰-L-賴氨酰-L-賴氨酰-L-蘇氨酰-L-絲氨酰-L-苯丙氨酰-L-谷氨酰胺酰-L-精氨酰-L-丙氨酰-L-賴氨酰-L-絲氨酸
SFRNGVGTGMKKTSFQRAKS
NEUROPEPTIDE S (HUMAN)
Neuropeptide S, NPS, human
Neuropeptide S (huMan) NPS (huMan)
SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER
H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH
REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH
常見問題列表
EC50: 9.4 nM (neuropeptide S receptor)
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC 50 of 6.7 ± 2.4 nM, the binding of [ 125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ 125I I] Y10-NPS, [ 125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC 50 = 0.42 ± 0.12 nM).
Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.
| Animal Model: | Male C57Bl/6 mice |
| Dosage: | 0.1 nM, 1 nM |
| Administration: | Intracerebroventricular (i.c.v.) injection |
| Result: | Increased locomotor activity and promoted wakefulness. |