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402473-54-5

中文名稱 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
英文名稱 ONO-AE3-208
CAS 402473-54-5
分子式 C24H21FN2O3
分子量 404.43
MOL 文件 402473-54-5.mol
更新日期 2024/06/25 17:15:56
402473-54-5 結(jié)構(gòu)式 402473-54-5 結(jié)構(gòu)式

基本信息

中文別名
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
英文別名
AE 3-208
ONO-AE3-208
AE 3-208
ONO AE3 208
ONO-AE3-208
AE 3-208
ONO AE3 208
4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid
4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid
Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)662.4±55.0 °C(Predicted)
密度1.30
儲存條件-20°C
溶解度≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic
酸度系數(shù)(pKa)4.69±0.10(Predicted)
形態(tài)粉末
顏色白色至米色
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-509014-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
ONO-AE3-208
402473-54-52mg620元
2024/11/08HY-509014-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
ONO-AE3-208
402473-54-55mg1030元
2024/11/08HY-509014-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
ONO-AE3-208
402473-54-510mM * 1mLin DMSO1133元

常見問題列表

生物活性
ONO-AE3-208 是一種 EP4 拮抗劑,能夠抑制前列腺癌細(xì)胞的侵襲,遷移與代謝。
靶點(diǎn)

EP4

體外研究

ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.

體內(nèi)研究

ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.

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