39746-25-3
中文名稱
16,16-DIMETHYL PROSTAGLANDIN E2
英文名稱
16,16-DIMETHYL PROSTAGLANDIN E2
CAS
39746-25-3
分子式
C22H36O5
分子量
380.52
MOL 文件
39746-25-3.mol
39746-25-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T1004616,16-二甲基前列腺素E2
英文別名
15r)-13eopentyl)-
16,16-dimethyl-pge2
QAOBBBBDJSWHMU-WMBBNPMCSA-N
16,16-Dimethyl dinoprostone
Suppliedasayellow,viscousoil
16,16-DimethylprostaglandineE2
16,16-DIMETHYL PROSTAGLANDIN E2
16,16-Dimethylprostaglandin E2 methyl acetate solution
16,16-DIMETHYL PROSTAGLANDIN E2 SUPPLIED AS A YELLOW, VISCOUS OIL
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
閃點(diǎn)-13℃
儲(chǔ)存條件-20°C
溶解度Soluble in methyl acetate
形態(tài)methyl acetate solution
顏色Colorless to light yellow
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H225-H319-H336
危險(xiǎn)品標(biāo)志F,Xn,Xi
危險(xiǎn)類別碼11-20/21/22-36/37/38-67-66-36
安全說明16-26-36
危險(xiǎn)品運(yùn)輸編號(hào)UN 1231 3/PG 2
危險(xiǎn)品運(yùn)輸編號(hào)UN 1231 3/PG 2
WGK Germany3
WGK Germany3
常見問題列表
生物活性
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) 是一種具有口服活性的脊椎動(dòng)物造血干細(xì)胞 (HSCs) 穩(wěn)態(tài)關(guān)鍵調(diào)節(jié)劑。16,16-Dimethyl prostaglandin E2 可以通過 EP2/EP4 起作用，并與 Wnt 途徑相互作用。靶點(diǎn)
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EP2
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EP4
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體內(nèi)研究
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 μg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2 IMF-KO mice and restores epithelial proliferation and structure.
| Animal Model: | Tpl2 IMF-KO mice |
| Dosage: | 10 μg/kg |
| Administration: | IP; every 12 hours; for 8 days |
| Result: | Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure. |