常見問題列表
生物活性
VU0420373 是一個有效的血紅素傳感器系統(tǒng) (HssRS) 激活劑，EC50 為 10.7 μM，pEC50 為 4.97。VU0420373 誘導血紅素的生物合成，對發(fā)酵金黃色葡萄球菌有毒。靶點
EC50: 10.7 μM (HssRS)
pEC50: 4.97 (HssRS)
體外研究
VU0420373 (compound 2e) has an IC
50
of >60 μM for Newman aerobic and Newman anaerobic, respectively.
VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt
S. aureus
to a toxic concentration of heme (20 μM).