382180-17-8
中文名稱
N-羥基-N'-3-吡啶基辛二酰胺
英文名稱
Pyroxamide
CAS
382180-17-8
分子式
C13H19N3O3
分子量
265.31
MOL 文件
382180-17-8.mol
更新日期
2024/07/15 17:10:55
382180-17-8 結(jié)構(gòu)式
基本信息
中文別名
N-羥基-N'-3-吡啶基辛二酰胺 英文別名
PyroxamideNSC 696085
Pyroxamide
PyroxaMide (NSC 696085)
Pyroxamide ISO 9001：2015 REACH
N-Hydroxy-N'-3-pyridinyloctanediamide
N1-Hydroxy-N8-3-pyridinyl-octanediamide
n-hydroxy-n'-(pyridin-3-yl)octanediamide
Octanediamide, N1-hydroxy-N8-3-pyridinyl-
N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
所屬類別
醫(yī)藥中間體：羥基吡啶安全數(shù)據(jù)
N-羥基-N'-3-吡啶基辛二酰胺價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-13216 | N-羥基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 5mg | 500元 |
| 2024/11/08 | HY-13216 | N-羥基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-13216 | N-羥基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 10mg | 850元 |
常見(jiàn)問(wèn)題列表
生物活性
Pyroxamide 是一種有效的組蛋白脫乙?；?1 (HDAC1) 抑制劑，ID50 為 100 nM。 Pyroxamide 可以誘導(dǎo)白血病細(xì)胞凋亡和細(xì)胞周期停滯。靶點(diǎn)
ID50: 100 nM
體外研究
Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1?fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively.
Cell Viability Assay
| Cell Line: | RD cells; RH30B cells |
| Concentration: | 1.25-20.0 μM |
| Incubation Time: | 24 hours; 48 hours; 72 hours |
| Result: | Resulted in a cell growth decrease in RD and RH30B cells. |
Cell Cycle Analysis
| Cell Line: | RD cells; RH30B cells |
| Concentration: | 10.0 μM; 20.0 μM |
| Incubation Time: | 48 hours |
| Result: | Increased the sub-G1?fractions at 48 hours compared with control samples. |