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38213-69-3

中文名稱 雙(麥芽醇)氧釩(IV)
英文名稱 Bis(maltolato)oxovanadium(IV)
CAS 38213-69-3
分子式 C12H10O7V
分子量 317.15
MOL 文件 38213-69-3.mol
更新日期 2023/03/20 15:41:17
38213-69-3 結(jié)構(gòu)式 38213-69-3 結(jié)構(gòu)式

基本信息

中文別名
雙(麥芽醇)氧釩(IV)
英文別名
BMOV
BIS(MALTOLATO)OXOVANADIUM
BIS(MALTOLATO)OXOVANADIUM(IV)
oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate)
(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM
Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-
所屬類別
原料藥

物理化學(xué)性質(zhì)

熔點(diǎn)>300°C (dec.)
儲(chǔ)存條件Refrigerator
溶解度DMSO(少許)、甲醇(少許)、水(少許)
形態(tài)粉末
顏色黃色到灰色到棕色
LogP0.079 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
防范說明P301+P310
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
WGK Germany3

常見問題列表

生物活性
BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一種有效的口服釩復(fù)合物,具有抗糖尿病特性和模仿胰島素的作用。BMOV被證明可改善糖尿病模型的心臟功能障礙。
靶點(diǎn)

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)

體外研究

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.

體內(nèi)研究

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
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