382-44-5
382-44-5 結(jié)構(gòu)式
基本信息
11Β-羥基雄甾-4-烯-3
4-雄甾烯-11-醇-3,17-二酮
4-雄烯-11β-醇-3,17-二酮
11β-羥基雄甾-4-烯-3,17-二酮
4-雄甾烯11Β-醇-3,17二酮-[D7]
11BETA-羥基-4-雄甾烯-3,17-二酮
4-雄甾烯-11Β-OL-3,17-二酮-2,2,4,6,6,16,16-D7
4-雄烯-11B-醇-3,17-二酮(2,2,4,6,6,16,16-D7,98%)
-dione
diol-d10
14&alpha
Decadiene
-9-
21-
20-
16-
15-
物理化學(xué)性質(zhì)
常見問題列表
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Human Endogenous Metabolite
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In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.