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38020-45-0

中文名稱 RMI 10874
英文名稱 RMI 10874
CAS 38020-45-0
分子式 C21H26N2O4
分子量 370.44
MOL 文件 38020-45-0.mol
38020-45-0 結(jié)構(gòu)式 38020-45-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12740
英文別名
RMI 10874
9H-Xanthen-9-one, 3,6-bis[2-(dimethylamino)ethoxy]-

物理化學性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
RMI 10874 是一種 Tilorone 類似物。Tilorone 是一種小分子口服有效的抗病毒劑。RMI 10874 完全消除 H-2 陰性 (GR9.B9) MCA 誘導的纖維肉瘤的肺孢子菌定植。
體內(nèi)研究

The effect of RMI 10874 (RMI 10,874DA) in the abrogation of the metastatic spread of tumor cells is studied. Pre-treatment of BALB/c mice with the RMI 10,874DA completely eliminates lung colonization of an H-2-negative (GR9.B9) MCA-induced fibrosarcoma clone in an experimental metastasis assay. The effect of a tilorone analogue (RMI 10,874DA) and anti-asialo GM 1 serum is studied on the survival of BALB/c and C57B1/6 mice after i.v. injections of different syngeneic murine tumor cells. Natural killer (NK) cell activation in vivo by RMI 10874 prolongs survival and inhibits metastasis formation in mice, even when pretreatment consists of a single dose of the analogue. Tilorone is a small-molecule, orally bioavailable drug that is used clinically as an antiviral.

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