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363571-83-9

中文名稱 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide
英文名稱 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide
CAS 363571-83-9
分子式 C20H16Br2N4O4
分子量 536.17
MOL 文件 363571-83-9.mol
363571-83-9 結(jié)構(gòu)式 363571-83-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15663
英文別名
3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide
Benzoic acid, 3,5-dibromo-4-hydroxy-, 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide

物理化學(xué)性質(zhì)

密度1.71±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 125 mg/mL (233.14 mM)
酸度系數(shù)(pKa)5.43±0.25(Predicted)
形態(tài)Solid
顏色Light yellow to yellow

常見問題列表

生物活性
Kinesore 是 KLC2-SKIP 相互作用的抑制劑。
靶點(diǎn)

KLC2-SKIP.

體外研究

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1.

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