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35865-33-9

中文名稱 DIANEMYCIN
英文名稱 dianemycin
CAS 35865-33-9
分子式 C47H78O14
分子量 867.11
MOL 文件 35865-33-9.mol
35865-33-9 結(jié)構(gòu)式 35865-33-9 結(jié)構(gòu)式

基本信息

中文別名
獵神霉素
KURASOIN
化合物DIANEMYCIN
英文別名
Nsc138320
dianemycin
Nanchangmycin free acid
Nanchangmycin >=98% (HPLC)
6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5...

物理化學(xué)性質(zhì)

沸點700.37°C (rough estimate)
密度1.0559 (rough estimate)
折射率1.6130 (estimate)
儲存條件-20°C儲存
溶解度DMSO: 155 mg/mL (178.75 mM); Water: < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)4.59±0.21(Predicted)
形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
Dianemycin (Nanchangmycin free acid) 由 Streptomyces nanchangensis NS3226 產(chǎn)生的一種聚醚抗生素,抑制革蘭氏陽性菌。Nanchangmycin 也是一種抗 Zika 病毒的廣譜抗病毒藥物。
靶點

Bacteria
Zika virus

體外研究

Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria.
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC 50 s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.

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