357336-74-4
中文名稱
Seletracetam
英文名稱
Seletracetam
CAS
357336-74-4
分子式
C10H14F2N2O2
分子量
232.229
MOL 文件
357336-74-4.mol
357336-74-4 結(jié)構(gòu)式
物理化學性質(zhì)
沸點396.3±42.0 °C(Predicted)
密度1.321±0.06 g/cm3(Predicted)
儲存條件Store at -20°C, stored under nitrogen
酸度系數(shù)(pKa)15.74±0.50(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見問題列表
生物活性
Seletracetam (Ucb 44212) 是一種類似于抗癲癇藥 Levetiracetam 的類似物。Seletracetam 是一種用于癲癇研究的小分子 SV2A 調(diào)制劑。靶點
SV2A
體外研究
Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A.
Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner.
Seletracetam modifies rates of presynaptic release.
Seletracetam inhibits high-voltage-activated Ca2
+
currents and intracellular Ca2
+
increase in rat cortical neurons in vitro.