349093-44-3
中文名稱
1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
英文名稱
1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone
CAS
349093-44-3
分子式
C19H22N2O2
分子量
310.39
MOL 文件
349093-44-3.mol
更新日期
2024/12/15 19:35:19
349093-44-3 結(jié)構(gòu)式
基本信息
中文別名
化合物PTGR2-IN-221-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
英文別名
PTGR2-IN-1PTGR2-IN-22
1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone
PTGR2IN1,cells,inhibit,transcriptional,HEK293T,PTGR2 IN 1,PPARγ,PTGR-2-IN-1,Inhibitor
常見問題列表
生物活性
PTGR2-IN-1 是一種有效的 PTGR2 抑制劑，IC50 為 ~0.7 μM。PTGR2-IN-1 增加了轉(zhuǎn)染 PTGR2 的 HEK293T 細胞 15-keto-PGE2 依賴的 PPARγ 轉(zhuǎn)錄活性。體外研究
A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity.