340267-36-9
340267-36-9 結(jié)構(gòu)式
基本信息
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE
3-(4-methylsulfonylphenyl)-4-phenyl-5-(trifluoromethyl)-1,2-oxazole
Isoxazole, 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-121537 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE CAY10404 | 340267-36-9 | 5mg | 900元 |
| 2024/11/08 | HY-121537 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE CAY10404 | 340267-36-9 | 10mM * 1mLin DMSO | 990元 |
| 2024/11/08 | HY-121537 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE CAY10404 | 340267-36-9 | 10mg | 1500元 |
常見問題列表
|
COX-2 1 nM (IC 50 ) |
COX-1 >500 μM (IC 50 ) |
Akt
|
CAY10404 (compound 7) exhibits no inhibition of COX-1 (IC
50
>500 μM).
CAY10404 (10-100 μM; for 3 days) inhibits the growth of NSCLC cell lines in a concentration-dependent manner and has an average 50% inhibitory concentration (IC
50
) of 60-100 μM.
CAY10404 (20-100 μM; for 3 days) induces apoptosis in NSCLC cells.
CAY10404 (80 μM; for 3 days) induces a concentration-dependent decrease in the level of the anti-apoptotic proteins (Bcl-2 and Bcl-X
L
) and pAkt and pGSK-3β.
CAY10404 (20, 50, 80, 100 μM; for 14 days) compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner.
Cell Viability Assay
| Cell Line: | Non-small cell lung cancer (NSCLC) cells (H1703, H358, H460) |
| Concentration: | 10-100 μM |
| Incubation Time: | For 3 days |
| Result: | Inhibited the growth of NSCLC cell lines in a concentration-dependent manner. |
Apoptosis Analysis
| Cell Line: | H460 cells |
| Concentration: | 20, 50, 100 μM |
| Incubation Time: | For 3 days |
| Result: | Induced apoptosis. |
Western Blot Analysis
| Cell Line: | NSCLC cells (H358, H460) |
| Concentration: | 80 μM |
| Incubation Time: | For 3 days |
| Result: | Induced a concentration-dependent decrease in the level of the anti-apoptotic proteins (Bcl-2 and Bcl-X L ) and pAkt and pGSK-3β, without changing the level of the pro-apoptotic protein (Bax) and total Akt and GSK-3β protein levels. |
CAY10404 (50 mg/kg/day; ip; for 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury.
| Animal Model: | Adult male C57Bl/6J mice weighing 24-30 g |
| Dosage: | 50 mg/kg |
| Administration: | IP; daily; for 4 days |
| Result: |
Attenuated cyclooxygenase activity, significantly decreasing BAL PGE2 and 6-keto PGF1α.
Decreased lung inflammation in HTV mice (high tidal volume; 20 ml/kg; for 4 hours) and attenuates ventilator-induced lung injury. |