3374-88-7
中文名稱
ICA
英文名稱
ICA
CAS
3374-88-7
分子式
C13H10N4S
分子量
254.31
MOL 文件
3374-88-7.mol
更新日期
2024/12/22 16:36:05
3374-88-7 結(jié)構(gòu)式
基本信息
英文別名
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)466.4±48.0 °C(Predicted)
密度1.339±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 49.5 mg/mL (194.64 mM)
酸度系數(shù)(pKa)3.20±0.10(Predicted)
形態(tài)Solid
顏色Light brown to brown
常見(jiàn)問(wèn)題列表
生物活性
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是SK通道 (SK channel) 抑制劑。ICA有抗利什曼原蟲(chóng)活性，IC50 值為2.1 μM。靶點(diǎn)
IC50: 2.1 μM (Antileishmanial)
體外研究
The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.