335276-86-3
中文名稱
化合物 T6702L
英文名稱
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1)
CAS
335276-86-3
分子式
C24H31NO3
分子量
381.52
MOL 文件
335276-86-3.mol
335276-86-3 結構式
基本信息
中文別名
化合物 T6702L 英文別名
DRG-0286Lamisil Krem
Terbinafine lactate
SF 86-327 hydrochloride
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1)
應用領域
用途一
Terbinafine is a synthetic allylamine antifungal, is used topically for skin infections. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. (last updated: 8/11/2016).