335165-68-9
中文名稱
BAI1
英文名稱
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CAS
335165-68-9
分子式
C19H21Br2N3O
分子量
467.2
MOL 文件
335165-68-9.mol
更新日期
2024/12/15 19:35:21
335165-68-9 結(jié)構(gòu)式
基本信息
中文別名
1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇3,6-二溴吲哚-ALPHA-(1-哌嗪甲基)-9H-咔唑-9-乙醇雙鹽酸鹽
英文別名
Bax channel blocke)-3-(piperazin-1-yL
BAX CHANNEL BLOCKER
Baxchannelblocker2HCl
1-(3,6-Dibromo-9H-carbazoL
Bax channel blocker(BAI-1)
9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
物理化學性質(zhì)
儲存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
形態(tài)固體
顏色白色
BAI1價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S8865 | BAI1 BAI1 | 335165-68-9 | 5mg | 876.42元 |
| 2024/11/08 | S8865 | BAI1 | 335165-68-9 | 10mM (1mL in DMSO) | 1040.13元 |
| 2024/11/08 | S8865 | BAI1 BAI1 | 335165-68-9 | 25mg | 2760.43元 |
常見問題列表
生物活性
BAI1是一種直接的BAX變構(gòu)抑制劑，Kd值為15.0 ± 4 μM。靶點
| Target | Value |
|
Bax
(Cell-free assay) | 15.0 μM(Kd) |
體外研究
BAI1 selectively inhibits BAX-mediated apoptotic cell death.
BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC
50
of 3.3 μΜ.
Apoptosis Analysis
| Cell Line: | Mouse MEF |
| Concentration: | 0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited cell death in BAX-dependent manner. |