32385-58-3
中文名稱
S-[2-(4(5)-咪唑基)乙基]異硫脲氫溴酸鹽
英文名稱
IMETIT DIHYDROBROMIDE
CAS
32385-58-3
分子式
C6H12Br2N4S
分子量
332.06
MOL 文件
32385-58-3.mol
更新日期
2024/12/22 16:36:06
32385-58-3 結(jié)構(gòu)式
基本信息
中文別名
IMETIT 氫溴酸鹽S-[2-(4(5)-咪唑基)乙基]異硫脲氫溴酸鹽
英文別名
IMETIT DIHYDROBROMIDEVUF 8325 dihydrobromide
SKF 91105 dihydrobromide
S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr
IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE
5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
CarbaMiMidothioic acid, 2-(1H-iMidazol-4-yl)ethyl ester, dihydrobroMide
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at RT
溶解度H2O: soluble
溶解度可溶于水中
形態(tài)solid
顏色off-white
水溶解性Freely soluble in water, practically insoluble in acetone
/n
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26-36
WGK Germany3
WGK Germany3
常見問(wèn)題列表
生物活性
Imetit dihydrobromide (VUF 8325 dihydrobromide) 是組胺 H3 和 H4 受體的高親和力的強(qiáng)激動(dòng)劑，Ki 值分別為 0.3 和 2.7 nM。Imetit dihydrobromide 模擬組胺對(duì)嗜酸性粒細(xì)胞形狀改變的作用 (EC50=25 nM)。靶點(diǎn)
|
H 3 Receptor 0.3 nM (Ki) |
H 4 receptor 2.7 nM (Ki) |
體內(nèi)研究
Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 2.5, 5, 10 mg/kg |
| Administration: | i.p. (30 min before Apomorphine) |
| Result: | Reduced the licking response induced by Apomorphine. |