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321661-62-5

中文名稱 CSN-B
英文名稱 Csn-B
CAS 321661-62-5
分子式 C18H26O5
分子量 322.4
MOL 文件 321661-62-5.mol
更新日期 2024/12/17 08:54:12
321661-62-5 結(jié)構(gòu)式 321661-62-5 結(jié)構(gòu)式

基本信息

中文別名
化合物CYTOSPORONE B
NUR77激動劑(CYTOSPORONE B)
英文別名
Csn-B
Cytosporone B
Dothiorelone G
ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE
所屬類別
生物化工:激動劑抑制劑

物理化學性質(zhì)

沸點471.6±24.0 °C(Predicted)
密度1.126±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度二甲基亞砜:>20mg/mL
酸度系數(shù)(pKa)7.54±0.40(Predicted)
形態(tài)結(jié)晶固體
顏色白色至灰白色
InChIInChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChIKeyUVVWQQKSNZLUQA-UHFFFAOYSA-N
SMILESC1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
危險品標志Xn
危險類別碼22
WGK Germany3

圖譜信息

CSN-B價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-N2148CSN-B
Cytosporone B
321661-62-52mg770元
2024/11/08HY-N2148CSN-B
Cytosporone B
321661-62-55mg1100元
2024/11/08HY-N2148CSN-B
Cytosporone B
321661-62-510mM * 1mLin DMSO1365元

常見問題列表

生物活性
Cytosporone B是天然存在的核孤兒受體Nur77(NR4A1) 激動劑,EC50為0.278 nM。
靶點
TargetValue
Nur77
(Cell-free assay)
0.278 nM(EC50)
體外研究

Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC 50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells.

體內(nèi)研究

In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min.

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