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311309-27-0

中文名稱 NEUROPEPTIDE VF (124-131) (HUMAN)
英文名稱 H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2
CAS 311309-27-0
分子式 C45H72N14O10
分子量 969.14
MOL 文件 311309-27-0.mol
更新日期 2024/12/23 10:30:23
311309-27-0 結(jié)構(gòu)式 311309-27-0 結(jié)構(gòu)式

基本信息

英文別名
NPVF
V-8-F-NH2
Rat RFRP-3
V-8-F-NH2, NPVF
H2N-VPNLPQRF-AMIDE
RFamide-related peptide-3
Neuropeptide VF (124-131)
NEUROPEPTIDE VF (124-131) (HUMAN)
RFRP-3 human trifluoroacetate salt
H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2

物理化學(xué)性質(zhì)

密度1.45±0.1 g/cm3(Predicted)
儲(chǔ)存條件-15°C
酸度系數(shù)(pKa)13.23±0.20(Predicted)
形態(tài)粉末
顏色白色至灰白色
水溶解性Soluble to 2 mg/ml in 20% acetonitrile / Water

安全數(shù)據(jù)

WGK Germany3

常見問題列表

生物活性
RFRP-3 (Neuropeptide VF(124-131))(human),一種人GnIH 肽同源物,是一種促性腺激素分泌抑制 Ca2+ 動(dòng)員的有效抑制劑。RFRP-3(human) 是一種NPFF1 受體激動(dòng)劑,它抑制 forskolin (HY-15371) 誘導(dǎo)的 cAMP 生成的 IC50 值為 0.7 nM。
體外研究

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC 50 of 0.7 nM. Scatchard-plot analysis shows that 125 I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K d value and the B max values are 0.19 nM and 1.3 pM, respectively.RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K d = 0.19 nM).RFRP-3 (10 -8 to 10 -14 M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

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