300801-03-0
中文名稱
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
英文名稱
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
CAS
300801-03-0
分子式
C16H25CuN6O6
分子量
460.96
MOL 文件
300801-03-0.mol
更新日期
2024/12/26 10:13:59
300801-03-0 結(jié)構(gòu)式
基本信息
中文別名
GHK-CU 醋酸鹽銅肽GHK-CU(1:1)
藍(lán)銅肽GHK -CU 1:1醋酸鹽
英文別名
GHK-CuacetatGHK-Cu (acetate)
Glycyl-L-Histidyl-L-Lysine Copper acetate(1:1)
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate
所屬類別
生物化工：多肽應(yīng)用領(lǐng)域
用途一
GHK-Cu acetate is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities. It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts. GHK-Cu increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats. It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 μM.3 GHK-Cu (10 μg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.