283172-68-9
中文名稱(chēng)
283172-68-9
英文名稱(chēng)
WD2000-012547
CAS
283172-68-9
分子式
C17H14N2O
分子量
262.31
MOL 文件
283172-68-9.mol
283172-68-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13333 英文別名
WD2000-0125476H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl-
物理化學(xué)性質(zhì)
熔點(diǎn)249-255 °C (decomp)
沸點(diǎn)600.2±44.0 °C(Predicted)
密度1.270±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.94±0.20(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
WD2000-012547 是一種選擇性的 PARP-1 抑制劑，pKi 為 8.221。靶點(diǎn)
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PARP-1 8.221 (pKi) |
體外研究
Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pK i of 8.221.