283167-06-6
中文名稱
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
英文名稱
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
CAS
283167-06-6
分子式
C14H17FN2O2
分子量
264.3
MOL 文件
283167-06-6.mol
更新日期
2024/12/23 10:29:49
283167-06-6 結(jié)構(gòu)式
基本信息
中文別名
化合物FK962N-(1-乙?；哙?4-基)-4-氟苯甲酰胺
英文別名
FK962N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro-
物理化學(xué)性質(zhì)
儲存條件Sealed in dry,Room Temperature
溶解度Soluble in DMSO
形態(tài)Solid
顏色White to off-white
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 5mg | 1200元 |
| 2024/11/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 10 mM * 1 mLin DMSO | 1320元 |
| 2024/11/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 10mg | 1900元 |
常見問題列表
生物活性
FK962 是生長抑素 (somatostatin) 釋放的增強劑，具有認(rèn)知增強作用。靶點
Somatostatin release
體外研究
FK962 (1 nM-1 μM) significantly enhances high K + -evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca 2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
體內(nèi)研究
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.
| Animal Model: | Male Lister Hooded rats, weighing approximately 270-300 |
| Dosage: | 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg |
| Administration: | Administered i.p. |
| Result: | Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |